Vivitro Labs

Pulse Duplicator

Pulse Duplicator

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The ViVitro Pulse Duplicator system is the world’s most widely cited and most used in-vitro cardiovascular hydrodynamic testing system.

The ViVitro Pulse Duplicator simulates the function of the heart (left or right) by generating pulsatile flow through prosthetic heart valves placed in the Model Left Heart. Powered by the ViVitro SuperPump, it is composed of the ViVitro Model Left Heart, SuperPump, Flow Measuring System and ViViTest data acquisition system. The components work together to assess the performance of prosthetic heart valves under simulated cardiac conditions. The ViVitro Pulse Duplicator System is used by the US Food and Drug Administration and is recognised by regulatory bodies worldwide including TÜV, BSI and the Chinese SFDA.

The Pulse Duplicator System assesses the performance of cardiovascular devices and prosthetic heart valves under simulated cardiac conditions. It simulates physiological or other complex flow variations while allowing the user to vary the peripheral resistance and compliance of the system. Pressure ports and flow measuring locations allow for data to be collected from aortic or mitral sites. Transparent viewpoints allow multiple viewing angles of the valve including inflow and outflow.

Combined with the ViVitest software control system, it quickly, easily and reliably collects and analyzes physiological flow and pressure data. The ViVitest software also allows the user to easily modify and customize waveforms.

The ViVitro Pulse Duplicator System is cited in numerous studies throughout the world. Visit our Citation Database for the current list of applications and articles.

  • Flow and pressure readings can be collected and analyzed in real-time, meeting ISO 5840 requirements
  • Controls pulsatile fluid flows to simulate various cardiac flow conditions including arrhythmia, normal, hypo and hypertensive states at an assortment of cardiac outputs and beat rates
  • Transducer sites allow measurement of wall pressures in the atrium, ventricle, and aortic outflow tract
  • Flow can be measured directly at the aortic or mitral sites
  • Simulates cardiovascular peripheral resistance and compliance
  • Thin acrylic windows permit echo imaging, Doppler flow measurements, and PIV for interrogation of flow field regions
  • Allows hydrodynamic testing of heart valve replacements in order to assess mechanical and hemodynamic performance
  • Ventricle membrane to replicate the natural chamber flow
  • For testing other implantable cardiac devices including Occluder and Closure Devices, customizations, optional components, and accessories are available

ViVitest Data Acquisition System (DAS)

Product Code: PDA2010

ViVitest is part of the ViVitro Data Acquisition System (DAS) family of software products. Combined with the Pulse Duplicator System it collects hydrodynamic testing data to meet ISO 5840 requirements. ViVitest software controls the SuperPump while simultaneously measuring pressure and flow data. It monitors, processes, and reports data such as regurgitant fraction, effective orifice area (EOA), and other valve performance indicators.

A calibration wizard walks new users through the set-up process for quick system preparation for testing. Output files are available in .CSV format for easy analysis in Excel and MatLab.

Viscoelastic Impedance Adapter (VIA)

Product Code: VIA7991

The ViVitro Viscoelastic Impedance Adapter (VIA) works in conjunction with the SuperPump to produce more realistic physiological ventricular pressures. It consists of a fixed resistive element and two adjustable compliance chambers to simulate ventricular viscoelastic behavior.

  • Adjustable dP/dt ratio to produce both physiological and diseased cardiac models
  • Filters high frequency noise when testing prosthetic valves and aortic conduits
  • Easily adjusted